Baboon CD34+ Cells
Baboon primary cells (Papio anubis) isolated using validated methods. Available fresh or cryopreserved with viability guarantee. Contact us for cell-specific specifications.
Baboon CD34+ Cells Overview
Baboon CD34+ Cells are primary hematopoietic stem and progenitor cells (HSPCs) isolated from baboon (Papio spp.) bone marrow. The baboon is a premier large NHP model for hematopoietic stem cell transplantation, gene therapy, and xenotransplantation research due to its close physiological similarity to humans.
Common Applications
- Hematopoietic stem cell transplant and engraftment modeling
- Gene therapy vector development (lentiviral, AAV)
- Colony-forming unit (CFU) assays
- Xenotransplantation and tolerance induction research
Product Details
Cells are enriched by immunomagnetic CD34 selection from bone marrow aspirates and cryopreserved. Each lot ships with a Certificate of Analysis documenting viability, purity, and donor information. Available in 100K, 0.5M, and 1M cell counts.
About the Baboon
Papio anubis
Baboons are large Old World primates valuable for cardiovascular, reproductive, and xenotransplantation research.
Their size and physiological similarity to humans make them particularly useful for surgical studies and organ transplant research.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
Immunotoxicology Studies
Assess potential immunotoxic effects of drug candidates on immune cell populations and function.
Vaccine Development
Evaluate immunogenicity and T cell responses to vaccine antigens in preclinical models.
CAR-T & Cell Therapy Research
Source material for developing and testing chimeric antigen receptor constructs and adoptive cell therapies.
Cytokine Release Assays
Screen biologics for potential cytokine release syndrome risk using species-relevant immune cells.
Flow Cytometry & Immunophenotyping
Characterize immune cell subset distributions and surface marker expression profiles.
ADCC & CDC Assays
Evaluate antibody-dependent and complement-dependent cytotoxicity of therapeutic antibodies.
| Species | Baboon (Papio anubis) |
|---|---|
| Cell Type | CD34+ Hematopoietic Stem/Progenitor Cells |
| Cell Count | ≥10 × 10⁶ viable cells per vial (standard) |
| Viability (Fresh) | ≥90% |
| Viability (Post-Thaw) | ≥70% |
| Viability Method | Trypan blue exclusion or flow cytometry |
| Format | Fresh or cryopreserved |
| Cryopreservation Medium | Serum-containing medium with 10% DMSO |
| Isolation Method | Immunomagnetic positive selection (anti-CD34) from mobilized peripheral blood or bone marrow |
| Storage (Cryopreserved) | Liquid nitrogen vapor phase |
| Shipping (Fresh) | Ambient temperature, overnight delivery |
| Shipping (Cryopreserved) | Dry ice |
| Donor Information | Age, sex, and health status available |
| Testing | Pathogen-free per supplier SOPs |
Geographic Origins Guide
Select the optimal origin for your research requirements
US Bred Origin ★ MOST COMMON
captive
Baboons originated from African populations, and current research animals are bred in established USA colonies.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Typical purity is >85% CD34+ cells as assessed by flow cytometry. CD34+ cells are enriched by immunomagnetic positive selection from mobilized peripheral blood or bone marrow. Purity, viability, and colony-forming unit (CFU) data are available.
Yes. CD34+ cells are functional hematopoietic stem/progenitor cells capable of forming CFU-GM, BFU-E, and CFU-GEMM colonies in methylcellulose assays. Colony-forming data from representative lots are available on request.
Thaw rapidly at 37°C, dilute dropwise into pre-warmed StemSpan or equivalent serum-free medium. Centrifuge gently at 200g for 10 minutes. Resuspend and plate immediately for expansion or colony assays. DNase I (10 µg/mL) can be added to reduce clumping.
Post-thaw viability is typically ≥70%. Colony-forming capacity is maintained post-thaw. For optimal engraftment studies, fresh cells are recommended. Viability is assessed by trypan blue exclusion and 7-AAD flow cytometry.
Yes. Donor reservation is available. CD34+ cell yield varies significantly between donors. We can provide cells from G-CSF mobilized donors for higher yields on request.