Cynomolgus Monkey Bone Marrow Supernatant
Cynomolgus Monkey biological fluid sample (Macaca fascicularis) collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Cynomolgus Monkey Bone Marrow Supernatant Overview
Cynomolgus Monkey Bone Marrow Supernatant is research-grade cynomolgus macaque bone marrow intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Bone marrow provides access to hematopoietic stem cells and progenitor populations essential for hematology, oncology, and regenerative medicine research.
Common applications
- Hematopoietic stem cell (HSC) research
- Colony-forming unit (CFU) assays
- Bone marrow transplant modeling
- Hematological malignancy studies
- Myeloid and lymphoid differentiation research
Collection, processing & handling
Bone marrow is collected via aspiration with documented protocols. Available as whole aspirate, mononuclear cell preparations, or processed fractions. Shipped fresh or cryopreserved depending on downstream application requirements.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched peripheral blood for comparative hematopoiesis studies from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
About the Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
Hematopoiesis Research
Study cytokines, growth factors (SCF, TPO, EPO, G-CSF), and signaling molecules in the bone marrow microenvironment.
Bone Marrow Niche Biology
Evaluate extracellular matrix components, chemokines (SDF-1/CXCL12), and stromal factors that regulate stem cell maintenance.
Oncology & Hematologic Disease
Analyze tumor-derived factors, angiogenic mediators, and immune markers in the bone marrow compartment for leukemia and myeloma research.
Drug Development
Measure drug penetration into the bone marrow compartment for chemotherapy, immunotherapy, and targeted therapy PK studies.
Biomarker Discovery
Identify novel bone marrow-derived soluble biomarkers for disease staging, treatment response, and minimal residual disease monitoring.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Sample Type | Bone Marrow Supernatant |
| Collection Method | Bone marrow aspiration from iliac crest under anesthesia, centrifuged to collect supernatant |
| Appearance | Clear to slightly pink/red, plasma-like |
| Typical Yield | 1-5 mL supernatant per aspiration |
| Volume Options | 0.5 mL, 1 mL, 2 mL |
| Processing | Bone marrow aspirate centrifuged at 400g for 10 min; supernatant collected and aliquoted |
| Contamination Control | Peripheral blood dilution assessed; first-pull aspirates preferred |
| Storage Temperature | '-80°C |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Bone marrow is aspirated from the iliac crest under general anesthesia using standard bone marrow aspiration needles. The aspirate is immediately centrifuged to separate cells from the supernatant (plasma-like fraction). First-pull aspirates are preferred to minimize peripheral blood dilution.
Typical yield is 1-5 mL of supernatant per aspiration, depending on species and aspirate volume. Larger primates yield more. The supernatant contains soluble factors from the marrow microenvironment. Pooled samples are available on request.
Bone marrow supernatant is evaluated for clarity and degree of hemolysis. Peripheral blood dilution is assessed based on the ratio of first-pull to subsequent aspirates. Standard documentation includes collection volume, centrifugation parameters, and donor health records.
