Cynomolgus Monkey CSF (Cerebrospinal Fluid)
Cynomolgus Monkey cerebrospinal fluid (Macaca fascicularis) collected via cisterna magna puncture with minimal blood contamination. Valuable for CNS drug development, neurodegenerative disease research, and biomarker discovery.
The Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Geographic Origins
Common Research Applications
Cynomolgus Monkey CSF (Cerebrospinal Fluid) is research-grade cynomolgus macaque CSF (cerebrospinal fluid) intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies. Cyno Cerebrospinal fluid (CSF) provides direct access to CNS biomarkers, supporting neuroscience research and neurodegenerative disease studies.
Common applications
- CNS biomarker discovery and validation
- Neurodegenerative disease research (Alzheimer's, Parkinson's)
- Blood-brain barrier penetration studies
- Neuroinflammation and neuroimmunology
- Intrathecal drug delivery research
Collection, processing & handling
Cyno Cerebrospinal fluid is collected via lumbar puncture or cisternal tap using standardized protocols. Samples are processed and aliquoted to minimize freeze-thaw cycles for sensitive biomarker preservation. Shipped frozen with documented cold-chain logistics.Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies. Also available: matched serum for CNS-peripheral biomarker comparison from the same species for comprehensive study design.Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.CNS Drug Development
Measure CNS penetration and drug concentrations in cerebrospinal fluid.
Neurodegenerative Disease Research
Study biomarkers of Alzheimer's, Parkinson's, and other neurological conditions.
Blood-Brain Barrier Studies
Assess BBB integrity and drug transport mechanisms.
Neuroimmunology
Evaluate immune cell trafficking and inflammatory markers in the CNS compartment.
Biomarker Discovery
Identify novel CSF biomarkers for neurological diseases and drug effects.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Sample Type | Cerebrospinal Fluid (CSF) |
| Collection Method | Cisterna magna puncture or lumbar puncture |
| Blood Contamination | <10 RBC/µL |
| Appearance | Clear and colorless |
| Typical Yield | 0.5-2.0 mL per collection |
| Volume Options | 0.25 mL, 0.5 mL, 1 mL |
| Processing | Centrifuged and aliquoted within 1 hour |
| Storage Temperature | '-80°C |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
CSF is collected via cisterna magna puncture under anesthesia by trained veterinary staff. This method provides clean samples with minimal blood contamination. The procedure is well-tolerated and can be performed serially.
Typical yield ranges from 0.5-2.0 mL per collection depending on animal size and species. Larger primates (cynomolgus, rhesus) yield more than smaller species (marmoset). Multiple collections from the same animal are possible with appropriate intervals.
CSF is evaluated for clarity (clear, colorless), blood contamination (<10 RBC/µL for standard samples), and protein content. Samples with visible blood contamination are excluded unless specifically requested for method development.