Cynomolgus Monkey Hepatocytes (Plateable)
Primary Cynomolgus Monkey hepatocytes (Macaca fascicularis) with characterized CYP activity. Available as suspension, platable, or cryopreserved formats. Essential for drug metabolism, hepatotoxicity screening, and transporter studies.
The Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Geographic Origins
Common Research Applications
Cynomolgus Monkey Hepatocytes (Platable) is research-grade cynomolgus macaque hepatocytes intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Primary hepatocytes retain metabolic enzyme activity critical for ADME studies, drug metabolism research, and hepatotoxicity screening.
Common applications
- Drug metabolism and CYP450 induction studies
- Hepatotoxicity and cytotoxicity screening
- Transporter activity and drug-drug interactions
- Metabolic clearance and intrinsic clearance assays
- In vitro ADME and DMPK studies
Collection, processing & handling
Primary hepatocytes are isolated using collagenase perfusion with documented viability and plating efficiency. Available as fresh suspensions, cryopreserved vials, or plateable formats. Shipped with validated cold-chain logistics and handling protocols.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched liver tissue for in vivo correlation from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Drug Metabolism Studies
Evaluate Phase I and Phase II metabolic pathways using functional hepatocytes.
CYP450 Induction & Inhibition
Screen compounds for cytochrome P450 enzyme interactions.
Hepatotoxicity Screening
Assess potential liver toxicity of drug candidates in species-relevant models.
Transporter Studies
Evaluate hepatic uptake and efflux transporter activity.
Clearance Predictions
Generate intrinsic clearance data for PK predictions.
Metabolite Identification
Identify metabolites formed by hepatic biotransformation.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Cell Type | Primary Hepatocytes |
| Source | Liver tissue, enzymatic perfusion |
| Cell Count | 5 × 10⁶ viable cells per vial (typical) |
| Viability (Fresh) | ≥85% |
| Viability (Post-Thaw) | ≥70% |
| Plating Efficiency | ≥70% (platable grade) |
| Format Options | Suspension, Platable, or Cryopreserved |
| CYP Activity | Characterized for major CYP enzymes |
| Storage (Cryopreserved) | Liquid nitrogen vapor phase |
| Shipping (Fresh) | Cold, overnight delivery |
| Donor Information | Age, sex, liver function data available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Suspension hepatocytes are suitable for short-term metabolic studies in suspension culture. Platable hepatocytes undergo additional quality assessment and are guaranteed to attach and form monolayers for longer-term studies requiring cell adherence.
Thaw rapidly in 37°C water bath, dilute in hepatocyte thawing medium, centrifuge gently, resuspend in plating medium, and seed onto collagen-coated plates. Allow 4-6 hours for attachment before changing to incubation medium. Detailed protocols provided with each lot.
Each lot is characterized for major CYP enzyme activities including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Activity data is provided in the Certificate of Analysis. Custom characterization for additional enzymes available upon request.