Cynomolgus Monkey Liver Microsomes
Cynomolgus Monkey primary cells (Macaca fascicularis) isolated using validated methods. Available fresh or cryopreserved with viability guarantee. Contact us for cell-specific specifications.
The Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Geographic Origins
Common Research Applications
Cynomolgus Monkey Liver Microsomes are research-grade cynomolgus macaque liver microsomes intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Liver tissue is essential for DMPK studies, hepatotoxicity assessment, and metabolic disease research with preserved tissue architecture.
Common applications
- Drug metabolism and DMPK studies
- Hepatotoxicity and liver injury
- NAFLD/NASH research
- Hepatic fibrosis modeling
- Bile acid metabolism
Collection, processing & handling
Tissue is collected and processed with protocols designed to preserve downstream histology and molecular workflows. Available formats include fresh, frozen, OCT-embedded, or FFPE as appropriate. Cold-chain logistics with documented handling throughout.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: primary hepatocytes for functional metabolism studies from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Immunotoxicology Studies
Assess potential immunotoxic effects of drug candidates on immune cell populations and function.
Vaccine Development
Evaluate immunogenicity and T cell responses to vaccine antigens in preclinical models.
CAR-T & Cell Therapy Research
Source material for developing and testing chimeric antigen receptor constructs and adoptive cell therapies.
Cytokine Release Assays
Screen biologics for potential cytokine release syndrome risk using species-relevant immune cells.
Flow Cytometry & Immunophenotyping
Characterize immune cell subset distributions and surface marker expression profiles.
ADCC & CDC Assays
Evaluate antibody-dependent and complement-dependent cytotoxicity of therapeutic antibodies.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Product Type | Liver Microsomes (Microsomal Fraction) |
| Source Tissue | Liver |
| Preparation Method | Differential ultracentrifugation of liver homogenate; 9,000g pellet discarded, 100,000g pellet collected |
| Protein Concentration | Typically 10-20 mg/mL total protein |
| CYP Activity | Characterized for major CYP enzyme activities upon request |
| Format | Frozen suspension in microsomal storage buffer |
| Storage Buffer | 50 mM Tris-HCl (pH 7.4), 150 mM KCl, 1 mM EDTA, 20% glycerol |
| Storage Temperature | '-80°C; avoid repeated freeze-thaw cycles |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
| Testing | Protein concentration measured; CYP activity data available on request |
| Documentation | Certificate of Analysis with lot-specific data |
| Quality Control | SDS-PAGE verification of microsomal enrichment available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Liver microsomes contain the full complement of membrane-bound drug-metabolizing enzymes including CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5 equivalents, UGTs, and FMOs. CYP activity characterization data for major isoforms is available on request. Activity levels vary by species and individual donor.
Store at -80°C. Avoid repeated freeze-thaw cycles; aliquot upon first thaw if multiple experiments are planned. Thaw on ice immediately before use. Dilute to working concentration in incubation buffer just prior to the experiment. Microsomal protein is stable for years at -80°C when stored properly.
Standard protocol: 0.5 mg/mL microsomal protein, 1 mM NADPH (or NADPH-regenerating system), 100 mM potassium phosphate buffer (pH 7.4), 37°C incubation. Typical time points: 0, 5, 15, 30, 60 minutes. Adjust protein concentration based on CYP content for species-specific optimization.
Both individual donor and pooled donor (typically 3-10 donors) microsomes are available. Pooled preparations reduce inter-individual variability. Individual donor microsomes are useful for CYP phenotyping and genotype-phenotype correlation studies.
Each lot includes: total protein concentration (BCA/Bradford), CYP content (CO-difference spectrum when available), and a Certificate of Analysis. CYP isoform-specific activity data (using probe substrates) is available on request for an additional characterization fee.