Cynomolgus Monkey Spleen Mononuclear Cells (MNCs)
Cynomolgus Monkey spleen tissue (Macaca fascicularis) available fresh, snap-frozen, or FFPE. Collected via aseptic necropsy with full documentation. Suitable for histopathology, IHC, and molecular analysis.
The Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Geographic Origins
Common Research Applications
Cynomolgus Monkey Spleen Mononuclear Cells (MNCs) are research-grade cynomolgus macaque primary cells intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information including viability and purity data.
Splenic mononuclear cells offer a mixed lymphocyte population from secondary lymphoid tissue for comprehensive immune studies.
Common applications
- Lymphocyte function assays
- Immune cell profiling
- Antigen presentation studies
- Immunotoxicology
- Vaccine research
Collection, processing & handling
Samples are collected and processed using standardized protocols appropriate to the sample type. Packaging and shipping are configured for temperature-controlled logistics to preserve sample integrity for your specific workflow requirements.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Histopathology
Perform microscopic examination for toxicity assessment and disease characterization.
Immunohistochemistry
Localize protein expression and cellular markers in tissue sections.
RNA/DNA Extraction
Isolate nucleic acids for gene expression analysis and genomic studies.
Primary Cell Isolation
Source tissue-derived primary cells for in vitro studies.
Tissue Homogenates
Prepare extracts for protein analysis, enzyme activity, and drug quantification.
In Situ Hybridization
Detect specific nucleic acid sequences in preserved tissue architecture.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Sample Type | Tissue |
| Preservation Options | Fresh, Snap-frozen, FFPE, or OCT-embedded |
| Collection | Aseptic necropsy within 30 minutes post-mortem |
| Quality Assessment | Gross pathology examination |
| Size Options | As available, contact for specific requirements |
| Storage (Frozen) | '-80°C or liquid nitrogen |
| Storage (FFPE) | Room temperature |
| Shipping (Frozen) | Dry ice |
| Documentation | Necropsy report available |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
We offer fresh tissue (shipped on ice), snap-frozen tissue (-80°C or LN2), FFPE blocks (formalin-fixed, paraffin-embedded), and OCT-embedded frozen sections. Choose based on your downstream application: fresh for cell isolation, frozen for molecular work, FFPE for histology/IHC.
Yes, we can provide multiple tissues from the same donor animal. This is valuable for studies comparing tissue distribution or requiring matched samples. Contact us with your tissue list for availability.
Each tissue sample includes donor information (age, sex, health status), collection date, preservation method, and gross pathology notes. Full necropsy reports are available upon request.