Cynomolgus Monkey Vitreous Humor
Cynomolgus Monkey biological fluid sample (Macaca fascicularis) collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Cynomolgus Monkey Vitreous Humor Overview
Cynomolgus Monkey Vitreous Humour is research-grade cynomolgus macaque tissue intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Vitreous humor provides an ocular matrix for intravitreal drug delivery research and posterior segment biomarker studies.
Common applications
- Intravitreal drug delivery
- Posterior segment pharmacokinetics
- Diabetic eye disease research
- Vitreoretinal surgery research
- Ocular biomarker studies
Collection, processing & handling
Tissue is collected and processed with protocols designed to preserve downstream histology and molecular workflows. Available formats include fresh, frozen, OCT-embedded, or FFPE as appropriate. Cold-chain logistics with documented handling throughout.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
About the Cynomolgus Monkey
Macaca fascicularis
The cynomolgus macaque is the most widely used non-human primate in biomedical research, valued for its close physiological and immunological similarity to humans.
With over 60% genetic homology for key immune receptors, cynomolgus monkeys provide highly translatable data for drug development, making them ideal for immunology, infectious disease, and toxicology studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
Intravitreal Drug Development
Measure drug concentrations and half-life following intravitreal injection for ocular PK and sustained-release formulation studies.
Retinal Disease Research
Study biomarkers and pathological mediators associated with diabetic retinopathy, macular degeneration, and retinal detachment.
Blood-Retinal Barrier Studies
Assess inner and outer blood-retinal barrier integrity and permeability changes under disease or treatment conditions.
Posterior Segment Immunology
Evaluate inflammatory mediators (VEGF, cytokines, complement) in the vitreous compartment for uveitis and immune-mediated retinal diseases.
Ocular Biomarker Discovery
Identify novel proteomic, metabolomic, or lipidomic biomarkers in the posterior segment for ophthalmic drug development.
| Species | Cynomolgus Monkey (Macaca fascicularis) |
|---|---|
| Sample Type | Vitreous Humor |
| Collection Method | Pars plana vitreous tap (23-25G needle) or vitrectomy under anesthesia |
| Appearance | Clear, colorless, gel-like consistency |
| Typical Yield | 0.5-2.0 mL per eye (species-dependent) |
| Volume Options | 0.25 mL, 0.5 mL, 1 mL, pooled |
| Contamination Control | Visual inspection for blood; samples with visible hemorrhage excluded |
| Processing | Centrifuged to remove cellular debris, aliquoted within 1 hour of collection |
| Storage Temperature | '-80°C |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
mainland
Chinese-origin cynomolgus are no longer exported by China. Cynomolgus macaques are not native to China and were historically imported from Cambodia, Vietnam, Laos, and Indonesia. Current samples are sourced from US breeding colonies established from China-line imports.
Mauritian Origin ★ DEFINED GENETICS
island
Mauritian cynomolgus have limited MHC diversity due to founder effects, making them valuable for immunology studies requiring genetic consistency.
Cambodian Origin ★ SOUTHEAST ASIAN
mainland
Cambodian-origin animals offer a Southeast Asian source with genetics that have not been mixed with other country lineages in the same way seen in some China-line populations.
Vietnamese Origin ★ SOUTHEAST ASIAN
mainland
Vietnamese cynomolgus provide another Southeast Asian option for programs that require distinct lineage sourcing or supply chain diversification.
Indonesian Origin ★ ISLAND ORIGIN
island
Indonesian-origin cynomolgus were among the earliest origins used in preclinical research and represented one of the largest research populations before China entered the market.
Philippine Origin ★ ISLAND ORIGIN
island
Philippine-origin cynomolgus were one of the first origins used broadly in research, with a long history as a trusted and widely used model.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Vitreous humor is collected via pars plana vitreous tap using a 23-25G needle under general anesthesia, or during vitrectomy at necropsy. The procedure is performed by trained veterinary staff or ophthalmic surgeons. In terminal studies, both eyes are typically sampled.
Typical yield is 0.5-2.0 mL per eye depending on species size. Cynomolgus and rhesus monkeys yield approximately 1.5-2.0 mL, while marmosets yield approximately 0.3-0.5 mL. Pooled samples from multiple donors are available for larger volume needs.
Vitreous humor is evaluated for clarity and absence of visible hemorrhage. The gel-like consistency is maintained during collection. Samples are centrifuged to remove cellular debris before aliquoting. Samples with significant blood contamination are excluded from standard inventory.
