Rhesus Monkey Bronchoalveolar Lavage (BAL)
Rhesus Monkey biological fluid sample (Macaca mulatta) collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Rhesus Monkey Bronchoalveolar Lavage (BAL) Overview
Rhesus Monkey Bronchoalveolar Lavage (BAL) is research-grade rhesus macaque bronchoalveolar lavage (BAL) fluid intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Bronchoalveolar lavage (BAL) fluid provides direct access to pulmonary immune cells and biomarkers for respiratory research.
Common applications
- Pulmonary immunology and inflammation studies
- Inhaled drug delivery research
- Respiratory infection and disease models
- Alveolar macrophage studies
- Lung biomarker discovery
Collection, processing & handling
Bronchoalveolar lavage fluid is collected using standardized protocols with documented volumes and processing conditions. Samples are processed to preserve cellular and protein content for downstream immunological and biomarker analyses. Shipped frozen with cold-chain logistics.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched lung tissue for histopathological correlation from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
About the Rhesus Monkey
Macaca mulatta
The rhesus macaque is one of the most studied primate species, fundamental to biomedical research for over a century.
With ~93% genetic homology to humans and extensive immunological characterization, rhesus monkeys are essential for vaccine development, HIV/AIDS research, and neuroscience studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
Pulmonary Drug Development
Measure drug concentrations in the lung lining fluid for inhaled therapeutics PK and distribution studies.
Respiratory Immunology
Profile immune cell populations (macrophages, lymphocytes, neutrophils) and inflammatory mediators in the lung compartment.
Pulmonary Toxicology
Assess lung inflammation biomarkers (cytokines, total protein, LDH) for inhaled compound safety evaluation.
Infectious Disease Research
Study respiratory pathogens, host immune response, and mucosal immunity in NHP models of respiratory infection.
Lung Biomarker Discovery
Identify novel proteomic or lipidomic biomarkers in BAL fluid for respiratory disease models.
| Species | Rhesus Monkey (Macaca mulatta) |
|---|---|
| Sample Type | Bronchoalveolar Lavage (BAL) Fluid |
| Collection Method | Bronchoscopy-guided or blind BAL with sterile saline under anesthesia |
| Appearance | Clear to slightly turbid, depending on cellularity |
| Typical Yield | 10-50 mL return from 50-100 mL instilled saline |
| Volume Options | 5 mL, 10 mL, or full recovery volume |
| Cell Content | Variable; alveolar macrophages predominate in healthy subjects |
| Processing | Centrifuged to separate cellular and acellular fractions; aliquoted within 2 hours |
| Storage Temperature | '-80°C (acellular fraction) or liquid nitrogen (cellular fraction) |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
asia
Chinese-origin rhesus are commonly used in toxicology and translational safety programs, supported by established breeding colonies and robust historical datasets.
Indian Origin
india lineage
Indian-origin rhesus represent a historically important research lineage, maintained through domestic breeding programs with strong legacy use in biomedical studies.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
BAL is performed via bronchoscopy under general anesthesia. Sterile saline (typically 2-4 aliquots of 20-25 mL each) is instilled into a lung segment and recovered by gentle aspiration. Return volumes are typically 40-60% of instilled volume. The procedure is well-tolerated and can be performed serially.
Typical return is 10-50 mL depending on instilled volume and technique. Standard protocol uses 50-100 mL total instillation. Both cellular (cell pellet) and acellular (supernatant) fractions are available. Custom protocols (targeted segments, specific volumes) can be arranged.
BAL fluid is evaluated for return volume, clarity, and differential cell count (when cellular fraction is requested). Total protein concentration and cell viability data are available. Samples with significant blood contamination (traumatic tap) are excluded from standard inventory.