Rhesus Monkey Cerebrospinal Fluid (CSF)
Rhesus Monkey cerebrospinal fluid (Macaca mulatta) collected via cisterna magna puncture with minimal blood contamination. Valuable for CNS drug development, neurodegenerative disease research, and biomarker discovery.
Rhesus Monkey Cerebrospinal Fluid (CSF) Overview
Rhesus Monkey Cerebrospinal Fluid (CSF) is research-grade rhesus macaque cerebrospinal fluid (CSF) intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Cerebrospinal fluid (CSF) provides direct access to CNS biomarkers, supporting neuroscience research and neurodegenerative disease studies.
Common applications
- CNS biomarker discovery and validation
- Neurodegenerative disease research (Alzheimer's, Parkinson's)
- Blood-brain barrier penetration studies
- Neuroinflammation and neuroimmunology
- Intrathecal drug delivery research
Collection, processing & handling
Cerebrospinal fluid is collected via lumbar puncture or cisternal tap using standardized protocols. Samples are processed and aliquoted to minimize freeze-thaw cycles for sensitive biomarker preservation. Shipped frozen with documented cold-chain logistics.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched serum for CNS-peripheral biomarker comparison from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
About the Rhesus Monkey
Macaca mulatta
The rhesus macaque is one of the most studied primate species, fundamental to biomedical research for over a century.
With ~93% genetic homology to humans and extensive immunological characterization, rhesus monkeys are essential for vaccine development, HIV/AIDS research, and neuroscience studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
CNS Drug Development
Measure CNS penetration and drug concentrations in cerebrospinal fluid.
Neurodegenerative Disease Research
Study biomarkers of Alzheimer's, Parkinson's, and other neurological conditions.
Blood-Brain Barrier Studies
Assess BBB integrity and drug transport mechanisms.
Neuroimmunology
Evaluate immune cell trafficking and inflammatory markers in the CNS compartment.
Biomarker Discovery
Identify novel CSF biomarkers for neurological diseases and drug effects.
| Species | Rhesus Monkey (Macaca mulatta) |
|---|---|
| Sample Type | Cerebrospinal Fluid (CSF) |
| Collection Method | Cisterna magna puncture or lumbar puncture |
| Blood Contamination | <10 RBC/µL |
| Appearance | Clear and colorless |
| Typical Yield | 0.5-2.0 mL per collection |
| Volume Options | 0.25 mL, 0.5 mL, 1 mL |
| Processing | Centrifuged and aliquoted within 1 hour |
| Storage Temperature | '-80°C |
| Shipping | Dry ice |
| Donor Information | Age, sex, and health status available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
asia
Chinese-origin rhesus are commonly used in toxicology and translational safety programs, supported by established breeding colonies and robust historical datasets.
Indian Origin
india lineage
Indian-origin rhesus represent a historically important research lineage, maintained through domestic breeding programs with strong legacy use in biomedical studies.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
CSF is collected via cisterna magna puncture under anesthesia by trained veterinary staff. This method provides clean samples with minimal blood contamination. The procedure is well-tolerated and can be performed serially.
Typical yield ranges from 0.5-2.0 mL per collection depending on animal size and species. Larger primates (cynomolgus, rhesus) yield more than smaller species (marmoset). Multiple collections from the same animal are possible with appropriate intervals.
CSF is evaluated for clarity (clear, colorless), blood contamination (<10 RBC/µL for standard samples), and protein content. Samples with visible blood contamination are excluded unless specifically requested for method development.