Rhesus Monkey Hepatocytes
Primary Rhesus Monkey hepatocytes (Macaca mulatta) with characterized CYP activity. Available as suspension, platable, or cryopreserved formats. Essential for drug metabolism, hepatotoxicity screening, and transporter studies.
Rhesus Monkey Hepatocytes Overview
Rhesus Monkey Hepatocytes is research-grade rhesus macaque hepatocytes intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Primary hepatocytes retain metabolic enzyme activity critical for ADME studies, drug metabolism research, and hepatotoxicity screening.
Common applications
- Drug metabolism and CYP450 induction studies
- Hepatotoxicity and cytotoxicity screening
- Transporter activity and drug-drug interactions
- Metabolic clearance and intrinsic clearance assays
- In vitro ADME and DMPK studies
Collection, processing & handling
Primary hepatocytes are isolated using collagenase perfusion with documented viability and plating efficiency. Available as fresh suspensions, cryopreserved vials, or plateable formats. Shipped with validated cold-chain logistics and handling protocols.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched liver tissue for in vivo correlation from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
About the Rhesus Monkey
Macaca mulatta
The rhesus macaque is one of the most studied primate species, fundamental to biomedical research for over a century.
With ~93% genetic homology to humans and extensive immunological characterization, rhesus monkeys are essential for vaccine development, HIV/AIDS research, and neuroscience studies.
Human Similarity
~93% genetic homology with extensive immune receptor cross-reactivity
Global Availability
Multiple geographic origins with established breeding colonies
Regulatory Accepted
FDA & EMA preferred species for biologics safety assessment
Origin Lineages at a Glance
Primary Research Areas
Drug Metabolism Studies
Evaluate Phase I and Phase II metabolic pathways using functional hepatocytes.
CYP450 Induction & Inhibition
Screen compounds for cytochrome P450 enzyme interactions.
Hepatotoxicity Screening
Assess potential liver toxicity of drug candidates in species-relevant models.
Transporter Studies
Evaluate hepatic uptake and efflux transporter activity.
Clearance Predictions
Generate intrinsic clearance data for PK predictions.
Metabolite Identification
Identify metabolites formed by hepatic biotransformation.
| Species | Rhesus Monkey (Macaca mulatta) |
|---|---|
| Cell Type | Primary Hepatocytes |
| Source | Liver tissue, enzymatic perfusion |
| Cell Count | 5 × 10⁶ viable cells per vial (typical) |
| Viability (Fresh) | ≥85% |
| Viability (Post-Thaw) | ≥70% |
| Plating Efficiency | ≥70% (platable grade) |
| Format Options | Suspension, Platable, or Cryopreserved |
| CYP Activity | Characterized for major CYP enzymes |
| Storage (Cryopreserved) | Liquid nitrogen vapor phase |
| Shipping (Fresh) | Cold, overnight delivery |
| Donor Information | Age, sex, liver function data available |
Geographic Origins Guide
Select the optimal origin for your research requirements
Chinese Origin ★ MOST COMMON
asia
Chinese-origin rhesus are commonly used in toxicology and translational safety programs, supported by established breeding colonies and robust historical datasets.
Indian Origin
india lineage
Indian-origin rhesus represent a historically important research lineage, maintained through domestic breeding programs with strong legacy use in biomedical studies.
Need help selecting an origin?
Our scientific team can advise on the optimal origin for your study design and regulatory requirements.
Suspension hepatocytes are suitable for short-term metabolic studies in suspension culture. Platable hepatocytes undergo additional quality assessment and are guaranteed to attach and form monolayers for longer-term studies requiring cell adherence.
Thaw rapidly in 37°C water bath, dilute in hepatocyte thawing medium, centrifuge gently, resuspend in plating medium, and seed onto collagen-coated plates. Allow 4-6 hours for attachment before changing to incubation medium. Detailed protocols provided with each lot.
Each lot is characterized for major CYP enzyme activities including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Activity data is provided in the Certificate of Analysis. Custom characterization for additional enzymes available upon request.