Sinclair Nanopig Hepatocytes (Plateable)
Sinclair Minipig hepatocytes available in suspension, platable, or spheroid formats. Ideal for drug metabolism and toxicology studies.
Sinclair Nanopig Hepatocytes (Plateable) Overview
Sinclair Nanopig Hepatocytes (Platable) is research-grade pig hepatocytes intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Primary hepatocytes retain metabolic enzyme activity critical for ADME studies, drug metabolism research, and hepatotoxicity screening.
Common applications
- Drug metabolism and CYP450 induction studies
- Hepatotoxicity and cytotoxicity screening
- Transporter activity and drug-drug interactions
- Metabolic clearance and intrinsic clearance assays
- In vitro ADME and DMPK studies
Collection, processing & handling
Primary hepatocytes are isolated using collagenase perfusion with documented viability and plating efficiency. Available as fresh suspensions, cryopreserved vials, or plateable formats. Shipped with validated cold-chain logistics and handling protocols.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched liver tissue for in vivo correlation from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, source, volumes, or custom handling requirements, request a quote and include your study specifications. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Sinclair Nanopig Overview
The Sinclair Nanopig is the smallest miniature swine line and is renowned for spontaneously developing cutaneous melanoma that regresses much like human melanoma, providing a unique large-animal model for oncology and dermatology research.
Quick Facts
Drug Metabolism
Study phase I and phase II drug metabolism using primary hepatocytes.
Hepatotoxicity Screening
Evaluate drug-induced liver injury in hepatocyte cultures.
CYP Induction Studies
Assess cytochrome P450 enzyme induction by drug candidates.
Transporter Studies
Investigate hepatic drug transporters and biliary excretion.
| Species | Sinclair Minipig |
|---|---|
| Sample Type | Hepatocytes |
| Health Status | SPF or Conventional |
| Storage | Format-dependent |
| Documentation | Certificate of Analysis, Health Records |
| Quality Control | Visual inspection, viability testing (cells) |
Swine are physiologically similar to humans in cardiovascular, GI, and skin systems, making them valuable translational models for drug development.
Standard products ship within 5-10 business days. Custom requests may require additional time.
Yes, we can accommodate specific collection requirements, processing protocols, and sample sizes.
Yes, multiple sample types from single donors can be arranged for comprehensive studies.