Sprague Dawley Rat Liver Microsomes
Sprague Dawley Rat (Rattus norvegicus) cell product collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Sprague Dawley Rat Liver Microsomes Overview
Sprague Dawley Rat Liver Microsomes is research-grade rat tissue intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Liver tissue is essential for DMPK studies, hepatotoxicity assessment, and metabolic disease research with preserved tissue architecture.
Available strains include Sprague Dawley and Wistar.
Common applications
- Drug metabolism and DMPK studies
- Hepatotoxicity and liver injury
- NAFLD/NASH research
- Hepatic fibrosis modeling
- Bile acid metabolism
Collection, processing & handling
Tissue is collected and processed with protocols designed to preserve downstream histology and molecular workflows. Available formats include fresh, frozen, OCT-embedded, or FFPE as appropriate. Cold-chain logistics with documented handling throughout.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: primary hepatocytes for functional metabolism studies from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, strain, volumes, or custom handling requirements, request a quote and include your study specifications. Available strains include Sprague Dawley and Wistar. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Sprague Dawley Rat Overview
The Sprague Dawley is an outbred albino rat and the most widely used rat strain in pharmacology, toxicology, and safety testing. Its calm temperament, rapid growth, and extensive historical control data make it a regulatory mainstay.
Quick Facts
Drug Metabolism Studies
Evaluate Phase I metabolism including CYP-mediated oxidation, reduction, and hydrolysis.
CYP Inhibition Screening
Assess potential for drug-drug interactions through CYP enzyme inhibition.
Metabolic Stability
Determine intrinsic clearance and half-life for compound optimization.
Reaction Phenotyping
Identify which CYP enzymes are responsible for drug metabolism.
Metabolite Identification
Generate oxidative metabolites for structural identification and safety assessment.
In Vitro Clearance Predictions
Predict in vivo clearance from microsomal intrinsic clearance data.
| Species | Sprague Dawley Rat (Rattus norvegicus) |
|---|---|
| Sample Type | Liver Microsomes |
| Preparation | Differential ultracentrifugation |
| Protein Content | 20 mg/mL (typical) |
| CYP Content | Characterized upon request |
| Storage | Frozen at -80C |
NADPH or NADPH-regenerating system is required for CYP-mediated reactions. UDP-glucuronic acid for UGT reactions.
Yes, we can provide CYP activity data using probe substrates upon request.
Yes, sex-specific microsomes are available. Pooled mixed-gender also available.
Typical assay concentration is 0.1-1.0 mg/mL protein depending on application.