Sprague Dawley Rat Spleen Mononuclear Cells (MNCs)
Sprague Dawley Rat (Rattus norvegicus) cell product collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Sprague Dawley Rat Spleen Mononuclear Cells (MNCs) Overview
Sprague Dawley Rat Spleen Mononuclear Cells (MNCs) are research-grade rat primary cells intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information including viability and purity data.
Splenic mononuclear cells offer a mixed lymphocyte population from secondary lymphoid tissue for comprehensive immune studies.
Common applications
- Lymphocyte function assays
- Immune cell profiling
- Antigen presentation studies
- Immunotoxicology
- Vaccine research
Collection, processing & handling
Samples are collected and processed using standardized protocols appropriate to the sample type. Packaging and shipping are configured for temperature-controlled logistics to preserve sample integrity for your specific workflow requirements.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Ordering notes
For specific donor criteria, strain, volumes, or custom handling requirements, request a quote and include your study specifications. Available strains include Sprague Dawley and Wistar. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Sprague Dawley Rat Overview
The Sprague Dawley is an outbred albino rat and the most widely used rat strain in pharmacology, toxicology, and safety testing. Its calm temperament, rapid growth, and extensive historical control data make it a regulatory mainstay.
Quick Facts
Immunophenotyping
Characterize splenic mononuclear cell populations.
Functional Assays
Assess immune cell function and responses.
Mixed Lymphocyte Reactions
Evaluate allogeneic immune responses.
Cytokine Studies
Measure cytokine production from splenic cells.
Cell Isolation
Source for isolating specific immune cell subsets.
Drug Screening
Evaluate immunomodulatory drug effects.
| Species | Sprague Dawley Rat (Rattus norvegicus) |
|---|---|
| Cell Type | Spleen Mononuclear Cells |
| Source | Fresh spleen tissue |
| Isolation Method | Mechanical dissociation and density gradient |
| Viability | >90% (typical) |
| Storage | Fresh or cryopreserved |
Spleen MNCs are enriched for lymphocytes through density gradient separation, removing RBCs and granulocytes.
Spleen MNCs contain T cells, B cells, NK cells, and monocytes.
Typical yield is 50-150 million MNCs per rat spleen.
Yes, we can further isolate T cells, B cells, or other subsets from spleen MNCs.