Wistar Rat Hepatocytes (Plateable)
Wistar Rat (Rattus norvegicus) cell product collected under controlled conditions. Processed promptly for optimal quality. Contact us for specifications and availability.
Wistar Rat Overview
The Wistar is the original laboratory rat strain and progenitor of many modern lines. This outbred albino rat is a versatile, well-characterized model used broadly across physiology, pharmacology, and behavioral research.
Quick Facts
Wistar Rat Hepatocytes (Platable) is research-grade rat hepatocytes intended for preclinical and translational research. Each order includes a Certificate of Analysis (COA) with lot-specific information and handling details to support consistency across studies.
Primary hepatocytes retain metabolic enzyme activity critical for ADME studies, drug metabolism research, and hepatotoxicity screening.
Common applications
- Drug metabolism and CYP450 induction studies
- Hepatotoxicity and cytotoxicity screening
- Transporter activity and drug-drug interactions
- Metabolic clearance and intrinsic clearance assays
- In vitro ADME and DMPK studies
Collection, processing & handling
Primary hepatocytes are isolated using collagenase perfusion with documented viability and plating efficiency. Available as fresh suspensions, cryopreserved vials, or plateable formats. Shipped with validated cold-chain logistics and handling protocols.
Quality control & documentation
QC testing options available on request, including material-appropriate analytical checks and extended documentation. Standard documentation includes collection/processing metadata, lot identifiers, and chain-of-custody records. Custom QC panels can be configured for GLP or regulatory-facing studies.
Also available: matched liver tissue for in vivo correlation from the same species for comprehensive study design.
Ordering notes
For specific donor criteria, strain, volumes, or custom handling requirements, request a quote and include your study specifications. Available strains include Sprague Dawley and Wistar. We routinely support longitudinal programs, matched sample sets, and custom collection protocols.
Drug Metabolism Studies
Evaluate Phase I and Phase II drug metabolism, enzyme induction, and metabolic stability.
CYP450 Profiling
Characterize cytochrome P450 enzyme activity and drug-drug interaction potential.
Hepatotoxicity Screening
Assess drug-induced liver injury potential in primary hepatocyte cultures.
Transporter Studies
Evaluate hepatic uptake and efflux transporter activity and inhibition.
Metabolite Identification
Generate and identify drug metabolites for safety and clearance studies.
In Vitro Clearance
Determine intrinsic clearance for ADME predictions and compound optimization.
| Species | Wistar Rat (Rattus norvegicus) |
|---|---|
| Cell Type | Primary Hepatocytes |
| Source | Fresh liver tissue |
| Isolation Method | Two-step collagenase perfusion |
| Viability | >85% (typical) |
| Formats | Suspension, Platable, or Spheroid |
Suspension hepatocytes are for short-term studies (4-6 hours). Platable hepatocytes can be cultured for days and maintain enzyme activity longer.
Yes, we provide CYP activity data upon request. Custom characterization available.
Typical seeding density is 0.5-1 million cells/mL for suspension or 50,000-100,000 cells/cm2 for plated cultures.
Yes, we offer hepatocytes validated for 3D spheroid culture for long-term studies.